Human Gamma Globulin.
نویسنده
چکیده
منابع مشابه
Properties of Various Anti-γ-globulin Factors in Human Sera
The serological and physicochemical properties of the following three forms of human anti-gamma-globulin factors were compared: (a) rheumatoid factors; (b) Milgrom type anti-gamma-globulin factors; and (c) factors directed against an antigen in human gammaG-globulin that is hidden in the intact molecule and revealed by enzymatic digestion at low pH. The property common to these factors is abili...
متن کاملEvidence for Species' Differences in the Effect of Serum Γ-globulin Concentration on Γ-globulin Catabolism
The fractional rates of catabolism of isotopically labeled mouse, human, bovine, and guinea pig gamma-globulins and human serum albumin were determined in mice and in guinea pigs whose serum gamma-globulin and serum albumin levels were elevated by immunization or by injections of exogenous serum proteins. These serum proteins were also followed in mice with different serum gamma-globulin levels...
متن کاملGamma Globulin Metabolism in Rabbits during T H E Anamnestic Response* by Evangelos
A number of diseases in man are associated with markedly increased gamma globulin levels in the serum and an even greater increase in total gamma globulin pool. The most striking of these is multiple myeloma, but elevations are also seen in cirrhosis of the liver, certain of the collagen diseases such as lupus erythematosus and rheumatoid arthritis, and a variety of chronic infectious processes...
متن کاملInteraction of the Rheumatoid Factor with Antigen-antibody Complexes and Aggregated Gamma Globulin
The effect of highly purified rheumatoid factor on the precipitin reactions of various antigen-antibody systems was determined. The amount of nitrogen precipitated was increased over a broad range when the factor was added to ovalbumin, human albumin, or human gamma globulin, and the corresponding rabbit antibodies. In the zone of antigen excess, soluble antigen-antibody complexes were precipit...
متن کاملThe Induction of a Rheumatoid Factor-like Substance in Rabbits
Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mer...
متن کاملStudies of Human Anti-γ-globulin Factors Reacting with Pepsin-digested Γ-globulins
Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhi...
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ورودعنوان ژورنال:
- Blood
دوره 25 شماره
صفحات -
تاریخ انتشار 1965